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Avoiding the innovation island in infrastructure mega-project

Hongquan CHEN, Quanke SU, Saixing ZENG, Daxin SUN, Jonathan Jingsheng SHI

《工程管理前沿（英文）》 2018年第5卷第1期页码 109-124 doi: 10.15302/J-FEM-2018073

摘要： Infrastructure mega-project (IMP) innovation is a complex process characterized by highly diverse innovators, a dynamic life-cycle, and stickiness of innovation knowledge. The IMP’s innovation network can be easily broken due to the fact that the network involves many different innovators across different industries and different projects. Further reasons for the fragility of the IMP’s innovation network are the dynamics of the IMP life-cycle, the diversity of the IMP’s innovative entities, the uniqueness of each IMP, and the temporary nature of each IMP’s organizations. The formed by the breaking of an IMP’s innovation network can stifle and harm innovation performance. Drawing from the knowledge-based view as well as innovation network theory, our research identifies the heterogeneous characte- ristics of IMP innovation. We propose a framework to analyze the formation mechanism of the IMP innovation island from three dimensions—the , the , and the . We look at the Hong Kong-Zhuhai-Macao Bridge project to elaborate the innovation island concept that negatively impacts IMP innovation. We also offer theoretical implications regarding the broader question of how IMPs can manage their innovation in practice.

关键词： innovation in mega-infrastructure projects the diversity of innovation bodies life-cycle dynamics the unique and temporary nature of IMPs innovation island

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Uncovering the evolution of tin use in the United States and its implications

《环境科学与工程前沿（英文）》 2021年第15卷第6期 doi: 10.1007/s11783-021-1406-6

摘要：

• US tin use decreases as the GDP value added by manufacturing sector increases.

关键词： Tin use GDP Curve fitting Logistic model Gompertz model

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Absorption heat pump for waste heat reuse: current states and future development

Zhenyuan XU, Ruzhu WANG

《能源前沿（英文）》 2017年第11卷第4期页码 414-436 doi: 10.1007/s11708-017-0507-1

摘要： Absorption heat pump attracts increasing attention due to its advantages in low grade thermal energy utilization. It can be applied for waste heat reuse to save energy consumption, reduce environment pollution, and bring considerable economic benefit. In this paper, three important aspects for absorption heat pump for waste heat reuse are reviewed. In the first part, different absorption heat pump cycles are classified and introduced. Absorption heat pumps for heat amplification and absorption heat transformer for temperature upgrading are included. Both basic single effect cycles and advanced cycles for better performance are introduced. In the second part, different working pairs, including the water based working pairs, ammonia based working pairs, alcohol based working pairs, and halogenated hydrocarbon based working pairs, for absorption heat pump are classified based on the refrigerant. In the third part, the applications of the absorption heat pump and absorption heat transformer for waste heat reuse in different industries are introduced. Based on the reviews in the three aspects, essential summary and future perspective are presented at last.

关键词： absorption heat pump heat transformer waste heat working pair

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Creation and integration mechanism of instrumentation flexible developing system

Xiaoli XU, Qiushuang LIU

《机械工程前沿（英文）》 2011年第6卷第2期页码 235-240 doi: 10.1007/s11465-011-0122-5

摘要：

To solve many key technical problems during the development of modern instrumentation system integration and provide a new mode and fundamental technical equipment for the research and development (R&D) of modern instrumentation products, based on the concept of an instrumentation flexible developing system (IFDS), this paper discusses the creation and open flexible integration mechanism, perfects the integrated supporting environment and integrated system of the flexible interconnection, and constructs the new flexible integrated system. Based on the operation mechanism of the modern instrumentation developing system and the research and optimization of the rapid integration design method, the paper emphasizes the dynamic integrating method of multiple types of knowledge in a modern instrument R&D system, to effectively utilize the rich integrated resource and achieve rapid integration of the system. Applications show that the new IFDS can improve the integration level and efficiency of R&D of the modern instrumentation system, enforce the reliability of the system, shorten the R&D period, and reduce the development costs.

关键词： modern instrumentation developing flexible interconnection flexible integration mechanism rapid integration system dynamic integrating method

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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

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《医学前沿（英文）》 2015年第9卷第1期页码 108-111 doi: 10.1007/s11684-014-0344-0

摘要：

Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient’s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.

关键词： gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib

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Haloacetic acids in swimming pool and spa water in the United States and China

Xiaomao WANG,Garcia Leal M I,Xiaolu ZHANG,Hongwei YANG,Yuefeng XIE

《环境科学与工程前沿（英文）》 2014年第8卷第6期页码 820-824 doi: 10.1007/s11783-014-0712-7

摘要： The objective of this study is to investigate the occurrence of haloacetic acids (HAAs), a group of disinfection byproducts, in swimming pool and spa water. The samples were collected from six indoor pools, six outdoor pools and three spas in Pennsylvania, the United States, and from five outdoor pools and nine indoor pools in Beijing, China. Five HAAs (HAA5), including monochloroacetic acid, dichloroacetic acid, trichloroacetic acid, monobromoacetic acid, and dibromoacetic acid were analyzed. Total chlorine, pH and total organic carbon concentration were analyzed as well. Results indicated that the levels of HAA5 in swimming pools and spas in the United States ranged from 70 to 3980 μg·L , with an arithmetic average at 1440 μg·L and a median level at 1150 μg·L . These levels are much higher than the levels reported in chlorinated drinking water and are likely due to organic matters released from swimmers’ bodies. The levels of HAA5 in swimming pools in China ranged from 13 to 332 μg·L , with an arithmetic average at 117 μg·L and a median level at 114 μg·L . The lower HAA levels in swimming pools in China were due to the lower chlorine residuals. Results from this study can help water professionals to better understand the formation and stability of HAAs in chlorinated water and assess risks associated with exposures to HAAs in swimming pools and spas.

关键词： chlorination disinfection byproduct haloacetic acid swimming pool trihalomethane

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与运行状态无关的电力系统安全域的理论和方法概述 Feature Article

余贻鑫, 刘艳丽, 秦超, 杨添剀

《工程（英文）》 2020年第6卷第7期页码 754-777 doi: 10.1016/j.eng.2019.11.016

摘要：

在电力系统的一系列最优化问题中，如何综合地考虑潮流约束和各种稳定性约束，而又不影响计算速度，始终还是个难题。至于概率安全性评估的计算负担就更加难以想象。为了解决此类问题，本文提出了安全域（SR）的方法论，该方法论是在经典的逐点法基础上发展起来的全新方法论。天津大学自20世纪80年代开始并长期坚持安全域的研究，至今取得了如本文所述的一系列原创成果。本文所介绍的安全域主要是定义在功率注入空间上的，包括确保静态安全、暂态稳定、静态电压稳定和小扰动稳定的安全域。对于既定的网络拓扑（以及暂态事故的发生地点和清除过程）和系统元件参数，它们是唯一确定的，并且与运行状态无关。本文通过11个命题和相应的注释，简明而系统地介绍了这些电力系统安全域的基本概念、构成、动力学性质、拓扑学与几何学特征、实用边界的实用数学描述及其快速计算方法，以期为成体系地认知安全域方法学、开展后续研究与应用提供支持。在拓扑学与几何学特征方面，最重要的发现是，在功率注入空间上，在工程实际所关心的范围内，安全域的边界可用一个或少数几个超平面的并集表示。基于该特征，电力系统安全约束优化问题和概率安全性评估（风险分析）的计算时间可以按数量级减少。

关键词：安全域构成潮流安全静态电压稳定小扰动稳定暂态稳定动力学性质几何学与拓扑学特征超平面

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Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

Mao CHEN,Yonglin JU

《能源前沿（英文）》 2016年第10卷第1期页码 37-45 doi: 10.1007/s11708-015-0390-6

摘要： Compared with the traditional engines, the thermo-acoustic engines are relatively new and can act as the linear compressors for refrigerators. Many institutes have shown great interest in this kind of machine for its absence of moving mechanical part. In this paper, the influence of the dimensions of the main parts of the small-scale Stirling thermo-acoustic engine was numerically simulated using a computer code called DeltaEC. The resonator and the resonator cavity were found to be the most convenient and effective in improving the performance of the engine. Based on the numerical simulation, a small-scale Stirling thermo-acoustic engine were constructed and experimentally investigated. Currently, with a resonator length of only 1 m, the working frequency of the engine was decreased to 90 Hz and the onset temperature difference was decreased to 198.2 K.

关键词： thermo-acoustic Stirling engine small-scale simulation experiment

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Piezoresistive pressure sensor with high sensitivity for medical application using peninsula-island structure

Tingzhong XU, Hongyan WANG, Yong XIA, Zhiming ZHAO, Mimi HUANG, Jiuhong WANG, Libo ZHAO, Yulong ZHAO, Zhuangde JIANG

《机械工程前沿（英文）》 2017年第12卷第4期页码 546-553 doi: 10.1007/s11465-017-0447-9

摘要：

A novel micro-electromechanical systems piezoresistive pressure sensor with a diagonally positioned peninsula-island structure has high sensitivity for ultra-low-pressure measurement. The pressure sensor was designed with a working range of 0–500 Pa and had a high sensitivity of 0.06 mV·V⁻¹·Pa⁻¹. The trade-off between high sensitivity and linearity was alleviated. Moreover, the influence of the installation angle on the sensing chip output was analyzed, and an application experiment of the sensor was conducted using the built pipettor test platform. Findings indicated that the proposed pressure sensor had sufficient resolution ability and accuracy to detect the pressure variation in the pipettor chamber. Therefore, the proposed pressure sensor has strong potential for medical equipment application.

关键词： MEMS low pressure sensor peninsula-island ultra-high sensitivity medical application

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Discovery of small molecule degraders for modulating cell cycle

《医学前沿（英文）》页码 823-854 doi: 10.1007/s11684-023-1027-5

摘要： The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

关键词： PROTAC molecular glue degrader cell cycle CDK cyclin

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

《医学前沿（英文）》 2022年第16卷第3期页码 339-357 doi: 10.1007/s11684-022-0926-1

摘要： During mitosis, the allocation of genetic material concurs with organelle transformation and distribution. The coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression, cell fate determination, and organismal homeostasis. Small GTPases belonging to the Ras superfamily regulate various cell organelles during division. Being the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associated with cell organelle disruption in neoplastic and non-neoplastic diseases, such as cancer and Alzheimer’s disease. Recent discoveries shed light on the molecular properties of small GTPases as sophisticated modulators of a remarkably complex and perfect adaptors for rapid structure reformation. This review collects current knowledge on small GTPases in the regulation of cell organelles during mitosis and highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics during mitosis.

关键词： small GTPase cell organelle mitosis

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Gut microbiota and its implications in small bowel transplantation

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《医学前沿（英文）》 2018年第12卷第3期页码 239-248 doi: 10.1007/s11684-018-0617-0

摘要：

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.

关键词： gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker microbiota-targeted therapy

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中美洁净煤转化技术现状及发展趋势

吴彦丽,李文英,易群,谢克昌

《中国工程科学》 2015年第17卷第9期页码 133-139

摘要：

基于煤炭在中美两国能源结构中的重要地位，指出洁净煤转化技术仍将是2050年前两国解决煤炭利用和环境问题的主导技术。本文阐述了先进煤化工涉及的洁净煤转化技术现状及发展趋势，重点以煤气化、煤液化、煤制烯烃和煤制乙二醇等技术为例，指出未来中美两国应优先在化学链气化技术、合成气一步合成低碳烯烃、煤炭转化系统CO2减排等核心技术发展，在化工作用机制、化学反应机理、高效催化剂开发、新型反应器设计等基础领域展开合作的战略建议。

关键词：中国和美国；洁净煤技术；现状；发展趋势；战略建议

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Advances in newly developing therapy for chronic hepatitis C virus infection

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《医学前沿（英文）》 2014年第8卷第2期页码 166-174 doi: 10.1007/s11684-014-0334-2

摘要：

Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA) agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN+RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.

关键词： direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

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《医学前沿（英文）》 2013年第7卷第2期页码 157-171 doi: 10.1007/s11684-013-0272-4

摘要：

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.

关键词： non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling